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Article

Genetic control of resistance to hepatocarcinogenesis by the mouse Hpcr3 locus.

Hepatology (Baltimore, Md.) - 1 Aug 2008

Manenti Giacomo, Galvan Antonella, Falvella F Stefania, Pascale Rosa M, Spada Elena, Milani Silvano, Gonzalez Neira Anna, Feo Francesco, Dragani Tommaso A

Abstract excerpt

UNLABELLED: The genome of the BALB/c mouse strain provides alleles that dominantly inhibit hepatocellular tumor development in F1 crosses with the highly hepatocarcinogenesis-susceptible C3H/He strain. Genome-wide linkage analysis using a 1536-single-nucleotide polymorphism array in a (C3H/He x BALB/c)F2 intercross population treated with urethane to induce hepatocellular tumor development revealed a locus with a...

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PMID: 18666244
DOI: 10.1002/hep.22374

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