Article
Systems genetics of liver fibrosis: identification of fibrogenic and expression quantitative trait loci in the BXD murine reference population.
PloS one - 1 Jan 2014
Hall Rabea A, Liebe Roman, Hochrath Katrin, Kazakov Andrey, Alberts Rudi, Laufs Ulrich, Böhm Michael, Fischer Hans-Peter, Williams Robert W, Schughart Klaus, Weber Susanne N, Lammert Frank
Abstract excerpt
The progression of liver fibrosis in response to chronic injury varies considerably among individual patients. The underlying genetics is highly complex due to large numbers of potential genes, environmental factors and cell types involved. Here, we provide the first toxicogenomic analysis of liver fibrosis induced by carbon tetrachloride in the murine 'genetic reference panel' of recombinant inbred BXD lines....
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