Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polygenic control of hepatocarcinogenesis in Copenhagen x F344 rats.

International journal of cancer - 10 Aug 2004

De Miglio Maria R, Pascale Rosa M, Simile Maria M, Muroni Maria R, Virdis Patrizia, Kwong Kelvin M-T, Wong Leslie K L, Bosinco Giovanni M, Pulina Franca R, Calvisi Diego F, Frau Maddalena, Wood Geoffrey A, Archer Michael C, Feo Francesco

Abstract excerpt

Cop and CFF1 rats exhibit resistance to hepatocarcinogenesis, associated with high rates of remodeling of neoplastic lesions. We have mapped hepatocarcinogenesis susceptibility, resistance and remodeling loci affecting the number, volume and volume fraction of neoplastic nodules induced by the "resistant hepatocyte" model in male CFF2 rats. Three loci in significant linkage with the number or volume of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Mapping

Share to Epistasis, Genetic

Share to Gene Expression Regulation, Neoplastic

Share to Liver Neoplasms

Share to Rats, Inbred F344

Source

Identifiers

PMID: 15185337
DOI: 10.1002/ijc.20225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polygenic control of hepatocarcinogenesis in Copenhagen x F344 rats.PMID 15185337Read ↗

Hepatocellular carcinoma as a complex polygenic disease. Interpretive analysis of recent developments on genetic predisposition.Semantic proximity Read ↗

Chromosome mapping of multiple loci affecting the genetic predisposition to rat liver carcinogenesis.Semantic proximity Read ↗

Genetic control of resistance to hepatocarcinogenesis by the mouse Hpcr3 locus.Semantic proximity Read ↗

Identification of genetic loci controlling hepatocarcinogenesis on rat chromosomes 7 and 10.Semantic proximity Read ↗

Phenotypic reversion of rat neoplastic liver nodules is under genetic control.Semantic proximity Read ↗

Identification and chromosome mapping of loci predisposing to colorectal cancer that control Wnt/beta-catenin pathway and progression of early lesions in the rat.Semantic proximity Read ↗

Systems genetics of hepatocellular damage in vivo and in vitro: identification of a critical network on chromosome 11 in mouse.Semantic proximity Read ↗

Inheritance of resistance to promotion of preneoplastic liver lesions in Copenhagen rats.Semantic proximity Read ↗

Exploring multiple quantitative trait loci models of hepatic fibrosis in a mouse intercross.Semantic proximity Read ↗

Genetics of liver tumor susceptibility in mice.Semantic proximity Read ↗

Systems Genetics of Liver Fibrosis.Semantic proximity Read ↗

Hepatocarcinogenesis: a polygenic model of inherited predisposition to cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.