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Article

Hepatocarcinogenesis: a polygenic model of inherited predisposition to cancer.

Tumori - 1 Jan 2000

Dragani T A, Canzian F, Manenti G, Pierotti M A

Abstract excerpt

The murine inbred strain C3H provides an experimental model of inherited predisposition to hepatocellular cancer. Hepatocellular neoplastic lesions induced by chemical carcinogens reach a volume 10-100-fold greater in C3H mice than in genetically resistant strains. However, the huge strain differences in tumor size are explained by relatively small differences (10%-30%) in tumor cell kinetics. Genetic linkage...

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PMID: 8623496
DOI: 10.1177/030089169608200101

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