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Article

Positional mapping and candidate gene analysis of the mouse Ccs3 locus that regulates differential susceptibility to carcinogen-induced colorectal cancer.

PloS one - 1 Jan 2013

Meunier Charles, Van Der Kraak Lauren, Turbide Claire, Groulx Normand, Labouba Ingrid, Cingolani Pablo, Blanchette Mathieu, Yeretssian Garabet, Mes-Masson Anne-Marie, Saleh Maya, Beauchemin Nicole, Gros Philippe

Abstract excerpt

The Ccs3 locus on mouse chromosome 3 regulates differential susceptibility of A/J (A, susceptible) and C57BL/6J (B6, resistant) mouse strains to chemically-induced colorectal cancer (CRC). Here, we report the high-resolution positional mapping of the gene underlying the Ccs3 effect. Using phenotype/genotype correlation in a series of 33 AcB/BcA recombinant congenic mouse strains, as well as in groups of backcross...

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Identifiers

PMID: 23516545
DOI: 10.1371/journal.pone.0058733
PMCID: PMC3597735

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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