Characterization of a major colon cancer susceptibility locus (Ccs3) on mouse chromosome 3.

doi:10.1038/onc.2009.369

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Article

Characterization of a major colon cancer susceptibility locus (Ccs3) on mouse chromosome 3.

Oncogene - 4 Feb 2010

Meunier C, Cai J, Fortin A, Kwan T, Marquis J-F, Turbide C, Van Der Kraak L, Jothy S, Beauchemin N, Gros P

Abstract excerpt

Treatment of mice with the carcinogen azoxymethane (AOM) induces a number of lesions in the colon, including hyperplastic lesions, as well adenomas and carcinomas in situ. Inbred strains of mice show different responses to AOM-induced carcinogenesis. A/J mice are highly susceptible and develop a greater number of hyperplastic lesions and tumors (15-70 tumors per mouse) than resistant C57BL/6J mice (0-6 tumors per...

Topics

Animals
Azoxymethane
Carcinogens
Chromosome Mapping
Chromosomes, Mammalian
Colonic Neoplasms
Gene Expression
Gene Expression Profiling
Genetic Loci
Genetic Predisposition to Disease
Humans
Mice
Mice, Congenic
Oligonucleotide Array Sequence Analysis

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Open in PubMed

Identifiers

PMID: 19915610
DOI: 10.1038/onc.2009.369

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Sequence Homology, Nucleic Acid