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Article

A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation.

Nature structural & molecular biology - 1 Aug 2008

Nakanishi Shima, Sanderson Brian W, Delventhal Kym M, Bradford William D, Staehling-Hampton Karen, Shilatifard Ali

Abstract excerpt

Methylation of histone 3 lysine 4 (H3K4) by yeast Set1-COMPASS requires prior monoubiquitination of histone H2B. To define whether other residues within the histones are also required for H3K4 methylation, we systematically generated a complete library of the alanine substitutions of all of the residues of the four core histones in Saccharomyces cerevisiae. From this study we discovered that 18 residues within...

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Identifiers

PMID: 18622391
DOI: 10.1038/nsmb.1454
PMCID: PMC2562305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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