Article
A comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation.
Genes & development - 1 Aug 2008
Lin Yu-yi, Qi Yan, Lu Jin-ying, Pan Xuewen, Yuan Daniel S, Zhao Yingming, Bader Joel S, Boeke Jef D
Abstract excerpt
Histone acetylation and deacetylation are among the principal mechanisms by which chromatin is regulated during transcription, DNA silencing, and DNA repair. We analyzed patterns of genetic interactions uncovered during comprehensive genome-wide analyses in yeast to probe how histone acetyltransferase (HAT) and histone deacetylase (HDAC) protein complexes interact. The genetic interaction data unveil an...
Topics
- Acetylation
- Acetyltransferases
- Cluster Analysis
- DNA Repair
- Fungal Proteins
- Histone Acetyltransferases
- Histone Deacetylases
- Histones
- Kinetics
- Models, Biological
- Models, Genetic
- Mutation
- Protein Processing, Post-Translational