Article
Mutagenesis of pairwise combinations of histone amino-terminal tails reveals functional redundancy in budding yeast.
Proceedings of the National Academy of Sciences of the United States of America - 10 Apr 2012
Kim Jung-Ae, Hsu Jer-Yuan, Smith M Mitchell, Allis C David
Abstract excerpt
A large body of literature provides compelling evidence for the role of evolutionarily conserved core histone residues in various biological processes. However, site-directed mutagenesis of individual residues that are known to be sites of posttranslational modifications often does not result in clear phenotypic defects. In some cases, the combination of multiple mutations can give rise to stronger phenotypes,...
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