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Article

Pds5 regulates sister chromatid cohesion by controlling cohesin ATPase activity through the Eco1-Smc3 acetylation pathway.

Nucleic acids research - 5 May 2026

Choudhary Karan, Subramanian V A, Lizarovich Roy, Matityahu Avi, Dutta Sreejita, Onn Itay, Ganoth Assaf, Tsfadia Yossi, Kupiec Martin

Abstract excerpt

Cohesin is a highly conserved protein complex essential for sister chromatid cohesion (SCC) and proper chromosome segregation during cell division. Pds5, a critical cohesin subunit, is essential for the function and stability of the cohesin complex on chromatin. However, the precise molecular mechanisms underlying Pds5's essential role remain poorly understood. To elucidate Pds5 function, we employed a genetic...

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Identifiers

PMID: 42120045
DOI: 10.1093/nar/gkag474
PMCID: PMC13161558

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