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Article

Genetic evidence that the acetylation of the Smc3p subunit of cohesin modulates its ATP-bound state to promote cohesion establishment in Saccharomyces cerevisiae.

Genetics - 1 Aug 2010

Heidinger-Pauli Jill M, Onn Itay, Koshland Douglas

Abstract excerpt

Sister chromatid cohesion refers to the process by which sister chromatids are tethered together until the metaphase-to-anaphase transition. The evolutionarily conserved cohesin complex mediates sister chromatid cohesion. Cohesin not only ensures proper chromosome segregation, but also promotes high-fidelity DNA repair and transcriptional regulation. Two subunits of cohesin (Smc1p, Smc3p) are members of the...

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Share to Acetylation
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomal Proteins, Non-Histone

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Source

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Identifiers

PMID: 20498298
DOI: 10.1534/genetics.110.116871
PMCID: PMC2927753

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic evidence that the acetylation of the Smc3p subunit of cohesin modulates its ATP-bound state to promote cohesion establishment in Saccharomyces cerevisiae.PMID 20498298Read ↗

Identification of a region in the coiled-coil domain of Smc3 that is essential for cohesin activity.Semantic proximity Read ↗

Cohesin's ATPase activity couples cohesin loading onto DNA with Smc3 acetylation.Semantic proximity Read ↗

Closing the cohesin ring: structure and function of its Smc3-kleisin interface.Semantic proximity Read ↗

Pds5 regulates sister chromatid cohesion by controlling cohesin ATPase activity through the Eco1-Smc3 acetylation pathway.Semantic proximity Read ↗

A molecular determinant for the establishment of sister chromatid cohesion.Semantic proximity Read ↗

A role for the Smc3 hinge domain in the maintenance of sister chromatid cohesion.Semantic proximity Read ↗

Building sister chromatid cohesion: smc3 acetylation counteracts an antiestablishment activity.Semantic proximity Read ↗

Impairing Cohesin Smc1/3 Head Engagement Compensates for the Lack of Eco1 Function.Semantic proximity Read ↗

Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis.Semantic proximity Read ↗

Cohesins: chromosomal proteins that prevent premature separation of sister chromatids.Semantic proximity Read ↗

Cohesion promotes nucleolar structure and function.Semantic proximity Read ↗

Pds5 promotes and protects cohesin acetylation.Semantic proximity Read ↗

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