Article
Podocyte specific knock out of selenoproteins does not enhance nephropathy in streptozotocin diabetic C57BL/6 mice.
BMC nephrology - 22 Jul 2008
Blauwkamp Marsha N, Yu Jingcheng, Schin MaryLee A, Burke Kathleen A, Berry Marla J, Carlson Bradley A, Brosius Frank C, Koenig Ronald J
Abstract excerpt
BACKGROUND: Selenoproteins contain selenocysteine (Sec), commonly considered the 21st genetically encoded amino acid. Many selenoproteins, such as the glutathione peroxidases and thioredoxin reductases, protect cells against oxidative stress by functioning as antioxidants and/or through their roles in the maintenance of intracellular redox balance. Since oxidative stress has been implicated in the pathogenesis of...
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