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Article

Knockout of SOD1 promotes conversion of selenocysteine to dehydroalanine in murine hepatic GPX1 protein.

Free radical biology & medicine - 1 Jul 2011

Wang Shi Kui, Weaver Jeremy D, Zhang Sheng, Lei Xin Gen

Abstract excerpt

Se-dependent glutathione peroxidase-1 (GPX1) and Cu,Zn-superoxide dismutase (SOD1) are two major intracellular antioxidant enzymes. The purpose of this study was to elucidate the biochemical mechanisms for the 40% loss of hepatic GPX1 activity in SOD1(-/-) mice. Compared with the wild type (WT), the SOD1(-/-) mice showed no change in the total amount of GPX1 protein. However, their total enzyme protein exhibited...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21420488
DOI: 10.1016/j.freeradbiomed.2011.03.018
PMCID: PMC3109192

Genes

GPX1
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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