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Article

Specific excision of the selenocysteine tRNA[Ser]Sec (Trsp) gene in mouse liver demonstrates an essential role of selenoproteins in liver function.

The Journal of biological chemistry - 27 Feb 2004

Carlson Bradley A, Novoselov Sergey V, Kumaraswamy Easwari, Lee Byeong Jae, Anver Miriam R, Gladyshev Vadim N, Hatfield Dolph L

Abstract excerpt

Selenium is essential in mammalian embryonic development. However, in adults, selenoprotein levels in several organs including liver can be substantially reduced by selenium deficiency without any apparent change in phenotype. To address the role of selenoproteins in liver function, mice homozygous for a floxed allele encoding the selenocysteine (Sec) tRNA([Ser]Sec) gene were crossed with transgenic mice carrying...

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PMID: 14660662
DOI: 10.1074/jbc.M310470200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Specific excision of the selenocysteine tRNA[Ser]Sec (Trsp) gene in mouse liver demonstrates an essential role of selenoproteins in liver function.PMID 14660662Read ↗

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