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Article

Selective removal of the selenocysteine tRNA [Ser]Sec gene (Trsp) in mouse mammary epithelium.

Molecular and cellular biology - 1 Mar 2003

Kumaraswamy Easwari, Carlson Bradley A, Morgan Fanta, Miyoshi Keiko, Robinson Gertraud W, Su Dan, Wang Shulin, Southon Eileen, Tessarollo Lino, Lee Byeong Jae, Gladyshev Vadim N, Hennighausen Lothar, Hatfield Dolph L

Abstract excerpt

Mice homozygous for an allele encoding the selenocysteine (Sec) tRNA [Ser]Sec gene (Trsp) flanked by loxP sites were generated. Cre recombinase-dependent removal of Trsp in these mice was lethal to embryos. To investigate the role of Trsp in mouse mammary epithelium, we deleted this gene by using transgenic mice carrying the Cre recombinase gene under control of the mouse mammary tumor virus (MMTV) long terminal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12588969
DOI: 10.1128/MCB.23.5.1477-1488.2003
PMCID: PMC151713

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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