Article
Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice.
Antioxidants & redox signaling - 15 Jun 2011
Labunskyy Vyacheslav M, Lee Byung Cheon, Handy Diane E, Loscalzo Joseph, Hatfield Dolph L, Gladyshev Vadim N
Abstract excerpt
Selenium (Se) is an essential trace element in mammals that has been shown to exert its function through selenoproteins. Whereas optimal levels of Se in the diet have important health benefits, a recent clinical trial has suggested that supplemental intake of Se above the adequate level potentially may raise the risk of type 2 diabetes mellitus. However, the molecular mechanisms for the effect of dietary Se on...
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