Article
Sec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H2O2.
Cell death & disease - 22 May 2014
Peng X, Mandal P K, Kaminskyy V O, Lindqvist A, Conrad M, Arnér E S J
Abstract excerpt
It is commonly recognized that diabetic complications involve increased oxidative stress directly triggered by hyperglycemia. The most important cellular protective systems against such oxidative stress have yet remained unclear. Here we show that the selenoprotein thioredoxin reductase 1 (TrxR1), encoded by the Txnrd1 gene, is an essential enzyme for such protection. Individually grown Txnrd1 knockout...
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