Article
Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild-type selenoenzyme.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2011
Mannes Alexander M, Seiler Alexander, Bosello Valentina, Maiorino Matilde, Conrad Marcus
Abstract excerpt
Selenoproteins are expressed in many organisms, including bacteria, insects, fish, and mammals. Yet, it has remained obscure why some organisms rely on selenoproteins while others, like yeast and plants, express Cys-containing homologues. This study addressed the possible advantage of selenocysteine (Sec) vs. Cys in the essential selenoprotein glutathione peroxidase 4 (GPx4), using 4-hydroxy-tamoxifen-inducible...
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