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Article

Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2008

Lages Celine S, Suffia Isabelle, Velilla Paula A, Huang Bin, Warshaw Gregg, Hildeman David A, Belkaid Yasmin, Chougnet Claire

Abstract excerpt

Declines in immune function are well described in the elderly and are considered to contribute significantly to the disease burden in this population. Regulatory T cells (T(regs)), a CD4(+) T cell subset usually characterized by high CD25 expression, control the intensity of immune responses both in rodents and humans. However, because CD25 expression does not define all T(regs), especially in aged hosts, we...

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Identifiers

PMID: 18641321
DOI: 10.4049/jimmunol.181.3.1835
PMCID: PMC2587319

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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