Article
CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly.
Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2003
Haynes Laura, Eaton Sheri M, Burns Eve M, Randall Troy D, Swain Susan L
Abstract excerpt
Age-related declines in immune function have an impact on both primary and memory responses. In this study, we have examined the ability of naive CD4 T cells from young and aged T cell receptor transgenic mice to establish functional memory. We found that memory cells generated from young CD4 T cells responded well to antigen, even a year after generation, whereas memory cells derived from CD4 T cells from aged...
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