Article
Accelerated age-dependent transition of human regulatory T cells to effector memory phenotype.
International immunology - 1 Mar 2008
Santner-Nanan Brigitte, Seddiki Nabila, Zhu Erhua, Quent Verena, Kelleher Anthony, Fazekas de St Groth Barbara, Nanan Ralph
Abstract excerpt
We and others recently described a method for isolating viable forkhead boxp3 (FoxP3(+)) T regulatory cells (Tregs) by means of the surface phenotype CD4(+)CD127(lo)CD25(+). In this study, we used the new strategy to measure Treg numbers, phenotype and function at different ages. Mean percentages of CD4(+)CD127(lo)CD25(+) Tregs increased only slightly throughout life, from 6.10% in cord blood to 7.22% in PBMC...
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