Article
Non-regulatory CD8+CD45RO+CD25+ T-lymphocytes may compensate for the loss of antigen-inexperienced CD8+CD45RA+ T-cells in old age.
Biological chemistry - 1 May 2008
Herndler-Brandstetter Dietmar, Veel Ellen, Laschober Gerhard T, Pfister Gerald, Brunner Stefan, Walcher Susanne, Parson Walther, Lepperdinger Günter, Grubeck-Loebenstein Beatrix
Abstract excerpt
The age-related decline in immune system functions is responsible for the increased prevalence of infectious diseases and the low efficacy of vaccination in elderly individuals. In particular, the number of peripheral naive T-cells declines throughout life and they exhibit severe functional defects at advanced age. However, we have recently identified a non-regulatory CD8+CD45RO+ CD25+ T-cell subset that occurs...
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