Article
Aging correlates with reduction in regulatory-type cytokines and T cells in the gut mucosa.
Immunobiology - 1 Oct 2011
Santiago Andrezza F, Alves Andréa C, Oliveira Rafael P, Fernandes Raphaela M, Paula-Silva Josiely, Assis Frankcineia A, Carvalho Cláudia R, Weiner Howard L, Faria Ana Maria C
Abstract excerpt
Aging is reported to be associated with decline in oral tolerance induction, which is initiated at the intestinal mucosal surface. Herein, we examined the effect of aging in T cells and cytokines at the intestinal mucosa that might be involved in oral tolerance induction. Frequencies of regulatory-type IEL subsets such as TCRγδ(+) and TCRαβ(+)CD8αα(+) were lower in aged mice. Mucosal CD4(+)CD25(+)Foxp3(+) and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.