Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aging and human CD4(+) regulatory T cells.

Mechanisms of ageing and development - 1 Aug 2009

Hwang Kyung-A, Kim Hang-Rae, Kang Insoo

Abstract excerpt

Alterations in immunity that occur with aging likely contribute to the development of infection, malignancy and inflammatory diseases. Naturally occurring CD4(+) regulatory T cells (Treg) expressing high levels of CD25 and forkhead box P3 (FOXP3) are essential for regulating immune responses. Here we investigated the effect of aging on the number, phenotypes and function of CD4(+) Treg in humans. The frequency...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Interleukin-10
Share to Interleukin-2 Receptor alpha Subunit
Share to T-Lymphocytes, Regulatory

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune System

Share to CD4-Positive T-Lymphocytes

Share to Cytokines

Share to Forkhead Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 19540259
DOI: 10.1016/j.mad.2009.06.003
PMCID: PMC2753872

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aging and human CD4(+) regulatory T cells.PMID 19540259Read ↗

Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation.Semantic proximity Read ↗

The frequency of regulatory CD3+CD8+CD28- CD25+ T lymphocytes in human peripheral blood increases with age.Semantic proximity Read ↗

The Th17/Treg balance is disturbed during aging.Semantic proximity Read ↗

Accelerated age-dependent transition of human regulatory T cells to effector memory phenotype.Semantic proximity Read ↗

CD4+CD25-FoxP3+T cells: a distinct subset or a heterogeneous population?Semantic proximity Read ↗

Phenotypical characterization of regulatory T cells in humans and rodents.Semantic proximity Read ↗

Beyond FOXP3: a 20-year journey unravelling human regulatory T-cell heterogeneity.Semantic proximity Read ↗

Aging correlates with reduction in regulatory-type cytokines and T cells in the gut mucosa.Semantic proximity Read ↗

Defining Human Regulatory T Cells beyond FOXP3: The Need to Combine Phenotype with Function.Semantic proximity Read ↗

CD4+CD25+ regulatory T cells: I. Phenotype and physiology.Semantic proximity Read ↗

Regulatory T cells: a review.Semantic proximity Read ↗

Human FOXP3+ regulatory T cells in transplantation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.