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Article

Gene silencing and endogenous DNA methylation in mammalian cells.

Mutation research - 25 May 1998

Holliday R, Ho T

Abstract excerpt

It is known that transformed mammalian cells can spontaneously inactivate genes at low frequency by the de novo methylation of promoter sequences. It is usually assumed that this is due to DNA methyl transferase activity, but an alternative possibility is that 5-methyldCTP is present in these cells and can be directly incorporated into DNA. The ongoing repair of DNA containing 5-methylcytosine will produce...

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PMID: 9685696
DOI: 10.1016/s0027-5107(98)00034-7

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