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Article

Testing the SCE mechanism with non-poisoning topoisomerase II inhibitors.

Mutation research - 18 Oct 2001

Domínguez I, Pastor N, Mateos S, Cortés F

Abstract excerpt

There are controversial theoretical models about a possible involvement of DNA topoisomerase II (topo II) in the molecular mechanism of sister chromatid exchanges (SCEs). In order to clarify the role of this enzyme, if any, in such recombinational event, CHO parental AA8 and mutant EM9 cells, which shows and extremely high baseline frequency of SCE, have been treated with different doses of the non-poisoning...

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Identifiers

PMID: 11525909
DOI: 10.1016/s1383-5718(01)00241-8

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Testing the SCE mechanism with non-poisoning topoisomerase II inhibitors.PMID 11525909Read ↗

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Cytogenetic effects of inhibition of topoisomerase I or II activities in the CHO mutant EM9 and its parental line AA8.Semantic proximity Read ↗

High yield of endoreduplication induced by ICRF-193: a topoisomerase II catalytic inhibitor.Semantic proximity Read ↗

Higher G2 sensitivity to the induction of chromosomal damage in the CHO mutant EM9 than in its parental line AA8 by camptothecin, an inhibitor of DNA topoisomerase I.Semantic proximity Read ↗

Yeast as a genetic model system for studying topoisomerase inhibitors.Semantic proximity Read ↗

Abnormally high incidence of SCE in three successive cell cycles in the CHO mutant EM9 as detected by a three-way immunoperoxidase differential staining.Semantic proximity Read ↗

A high yield of translocations parallels the high yield of sister chromatid exchanges in the CHO mutant EM9.Semantic proximity Read ↗

Characterization of revertants of the CHO EM9 mutant arising during DNA transfection.Semantic proximity Read ↗

Topoisomerase activities and levels in irradiated Chinese hamster AA8 cells and in its radiosensitive mutant EM9.Semantic proximity Read ↗

Effect on SCE in human chromosomes in vitro of low-level pulsed magnetic field.Semantic proximity Read ↗

The high rate of endoreduplication in the repair deficient CHO mutant EM9 parallels a reduced level of methylated deoxycytidine in DNA.Semantic proximity Read ↗

Interference with topoisomerase IIalpha potentiates melphalan cytotoxicity.Semantic proximity Read ↗

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