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Article

Closed state structure of the pore revealed by uncoupled Shaker K+ channel.

Nature communications - 19 Nov 2025

Liu Yichen, Bassetto Carlos, Contreras Gustavo F, Perozo Eduardo, Bezanilla Francisco

Abstract excerpt

Voltage gated potassium (Kv) channels regulate processes from cellular excitability to immune response and are major pharmaceutical targets. Despite recent structural advances, the closed state structure of the strictly coupled Kv1 family remains elusive. Here, we capture the structure of the Shaker potassium channel with a closed pore by uncoupling its voltage sensor domains from the pore domain. Structural...

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Identifiers

PMID: 41261088
DOI: 10.1038/s41467-025-65124-0
PMCID: PMC12630689

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