Article
Semisynthetic K+ channels show that the constricted conformation of the selectivity filter is not the C-type inactivated state.
Proceedings of the National Academy of Sciences of the United States of America - 24 Sept 2013
Devaraneni Prasanna K, Komarov Alexander G, Costantino Corey A, Devereaux Jordan J, Matulef Kimberly, Valiyaveetil Francis I
Abstract excerpt
C-type inactivation of K(+) channels plays a key role in modulating cellular excitability. During C-type inactivation, the selectivity filter of a K(+) channel changes conformation from a conductive to a nonconductive state. Crystal structures of the KcsA channel determined at low K(+) or in the open state revealed a constricted conformation of the selectivity filter, which was proposed to represent the C-type...
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