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Article

Protonation state of E71 in KcsA and its role for channel collapse and inactivation.

Proceedings of the National Academy of Sciences of the United States of America - 18 Sept 2012

Bhate Manasi P, McDermott Ann E

Abstract excerpt

The prototypical prokaryotic potassium channel KcsA alters its pore depending on the ambient potassium; at high potassium, it exists in a conductive form, and at low potassium, it collapses into a nonconductive structure with reduced ion occupancy. We present solid-state NMR studies of KcsA in which we test the hypothesis that an important channel-inactivation process, known as C-type inactivation, proceeds via a...

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Identifiers

PMID: 22942391
DOI: 10.1073/pnas.1211900109
PMCID: PMC3458351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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