Article
Mechanism of activation gating in the full-length KcsA K+ channel.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 2011
Uysal Serdar, Cuello Luis G, Cortes D Marien, Koide Shohei, Kossiakoff Anthony A, Perozo Eduardo
Abstract excerpt
Using a constitutively active channel mutant, we solved the structure of full-length KcsA in the open conformation at 3.9 Å. The structure reveals that the activation gate expands about 20 Å, exerting a strain on the bulge helices in the C-terminal domain and generating side windows large enough to accommodate hydrated K(+) ions. Functional and spectroscopic analysis of the gating transition provides direct...
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