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Article

Structural and functional consequences of an amide-to-ester substitution in the selectivity filter of a potassium channel.

Journal of the American Chemical Society - 6 Sept 2006

Valiyaveetil Francis I, Sekedat Matthew, MacKinnon Roderick, Muir Tom W

Abstract excerpt

The selectivity filter of K(+) channels comprises four contiguous ion binding sites, S1 through S4. Structural and functional data indicate that the filter contains on average two K(+) ions at any given time and that these ions reside primarily in two configurations, namely to sites S1 and S3 or to sites S2 and S4. Maximum ion flux through the channel is expected to occur when the energy difference between these...

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Identifiers

PMID: 16939283
DOI: 10.1021/ja0631955
PMCID: PMC2546570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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