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Article

Structures of Gating Intermediates in a K+ channel.

Journal of molecular biology - 19 Nov 2021

Reddi Ravikumar, Matulef Kimberly, Riederer Erika, Moenne-Loccoz Pierre, Valiyaveetil Francis I

Abstract excerpt

Regulation of ion conduction through the pore of a K+ channel takes place through the coordinated action of the activation gate at the bundle crossing of the inner helices and the inactivation gate located at the selectivity filter. The mechanism of allosteric coupling of these gates is of key interest. Here we report new insights into this allosteric coupling mechanism from studies on a W67F mutant of the KcsA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34627789
DOI: 10.1016/j.jmb.2021.167296
PMCID: PMC8672811

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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