Article
Influence of multiple APOE genetic variants on cognitive function in a cohort of older men - results from the Normative Aging Study.
BMC psychiatry - 1 Aug 2014
Prada Diddier, Colicino Elena, Power Melinda C, Cox David G, Weisskopf Marc G, Hou Lifang, Spiro Iii Avron, Vokonas Pantel, Zhong Jia, Sanchez-Guerra Marco, Herrera Luis A, Schwartz Joel, Baccarelli Andrea A
Abstract excerpt
BACKGROUND: APOE is the biomarker with the greatest known influence on cognitive function; however, the effect of complex haplotypes involving polymorphisms rs449647, rs405509, rs440446, rs429358 and rs7412 has never been studied in older populations. METHODS: We evaluated APOE polymorphisms using multiplex PCR for genotyping and Mini-Mental State Examination (MMSE) to evaluate cognitive function in 819...