Longitudinal changes in cognition and behavior in asymptomatic carriers of the APOE e4 allele.

doi:10.1212/01.wnl.0000129533.26544.bf

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Article

Longitudinal changes in cognition and behavior in asymptomatic carriers of the APOE e4 allele.

Neurology - 8 Jun 2004

Caselli R J, Reiman E M, Osborne D, Hentz J G, Baxter L C, Hernandez J L, Alexander G G

Abstract excerpt

OBJECTIVE: To determine whether memory loss is detectable before the symptomatic presentation of mild cognitive impairment (MCI) in those at greater genetic risk for Alzheimer disease (AD) based upon presence or absence of the e4 allele of APOE. METHODS: Participants were age 50 years or older who responded to newspaper advertisements. A total of 212 cognitively normal individuals of known APOE genotype were...

Topics

Aged
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Arizona
Bias
Cognition
Cohort Studies
Depression
Female
Genetic Predisposition to Disease
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Language Tests

Longitudinal Studies

Male

Memory Disorders

Mental Recall

Source

Open in PubMed

Identifiers

PMID: 15184602
DOI: 10.1212/01.wnl.0000129533.26544.bf

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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