Apolipoprotein e4 allele and cognitive decline in elderly men.

doi:10.1136/bmj.309.6963.1202

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Article

Apolipoprotein e4 allele and cognitive decline in elderly men.

BMJ (Clinical research ed.) - 5 Nov 1994

Feskens E J, Havekes L M, Kalmijn S, de Knijff P, Launer L J, Kromhout D

Abstract excerpt

OBJECTIVES: To determine whether polymorphism of apolipoprotein E--notably, the e4 allele--predicts cognitive deterioration in the general population. DESIGN: Population based cohort investigated in 1990 and in 1993. SETTING: Zutphen, the Netherlands. SUBJECTS: Representative cohort of 538 Dutch...

Topics

Aged
Aged, 80 and over
Alleles
Apolipoprotein E4
Apolipoproteins E
Cognition Disorders
Cohort Studies
Humans
Incidence
Male
Netherlands
Odds Ratio
Polymorphism, Genetic
Prevalence
Risk Factors

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