Article
Association study of the paraoxonase 1 gene with the risk of developing Alzheimer's disease.
Neurobiology of aging - 1 Jan 2009
Chapuis Julien, Boscher Maud, Bensemain Faiza, Cottel Dominique, Amouyel Philippe, Lambert Jean-Charles
Abstract excerpt
Recently, a region encompassing the promoter and intron 1 of the paraoxonase 1 gene (PON1) have been associated with the risk of developing Alzheimer's disease (AD) in a large pan-ethnic (Caucasian and African-American) dataset. We attempted to replicate this observation in a large French study of sporadic cases and controls. We confirmed that the proximal promoter and 5' sequence of the PON1 gene may harbor...
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