Article
Paraoxonase cluster polymorphisms are associated with sporadic ALS.
Neurology - 12 Sept 2006
Saeed M, Siddique N, Hung W Y, Usacheva E, Liu E, Sufit R L, Heller S L, Haines J L, Pericak-Vance M, Siddique T
Abstract excerpt
BACKGROUND: Paraoxonases (PONs) are involved in the detoxification of organophosphate pesticides and chemical nerve agents. Due to a reported possible twofold increased risk of ALS in Gulf War veterans and the associations of PON1 polymorphisms with the neurologic symptom complex of the Gulf War syndrome, the authors investigated the association between sporadic ALS (SALS) and PON gene cluster variants in a large...
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