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Article

Polymorphisms in the PON gene cluster are associated with Alzheimer disease.

Human molecular genetics - 1 Jan 2006

Erlich Porat M, Lunetta Kathryn L, Cupples L Adrienne, Huyck Matthew, Green Robert C, Baldwin Clinton T, Farrer Lindsay A

Abstract excerpt

Paraoxonase is an arylesterase enzyme that is expressed in the liver and found in the circulation in association with apoA1 and the high-density lipoprotein, and prevents the accumulation of oxidized lipids in low-density lipoproteins in vitro. Common polymorphisms in genes encoding paraoxonase are established risk factors in a variety of vascular disorders including coronary artery disease and carotid artery...

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Source

Identifiers

PMID: 16319130
DOI: 10.1093/hmg/ddi428

Genes

PON1
PON2
PON3

Provenance

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Related research

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Research trail→

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Polymorphisms in the PON gene cluster are associated with Alzheimer disease.PMID 16319130Read ↗

Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.Semantic proximity Read ↗

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A comprehensive genetic association study of Alzheimer disease in African Americans.Semantic proximity Read ↗

Paraoxonase gene polymorphism and the risk for Alzheimer's disease in the polish population.Semantic proximity Read ↗

Additional Common Polymorphisms in thePONGene Cluster Predict PON1 Activity but Not Vascular DiseaseSemantic proximity Read ↗

A common haplotype within the PON1 promoter region is associated with sporadic ALS.Semantic proximity Read ↗

Involvement of paraoxonase 1 genetic variants in Alzheimer's disease neuropathology.Semantic proximity Read ↗

Paraoxonase 1 gene polymorphisms and dementia in humans.Semantic proximity Read ↗

Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.Semantic proximity Read ↗

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Genetic association between endothelial nitric oxide synthase and Alzheimer disease.Semantic proximity Read ↗

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