Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS.

Nature genetics - 1 Aug 2002

Martin Maureen P, Gao Xiaojiang, Lee Jeong-Hee, Nelson George W, Detels Roger, Goedert James J, Buchbinder Susan, Hoots Keith, Vlahov David, Trowsdale John, Wilson Michael, O'Brien Stephen J, Carrington Mary

Abstract excerpt

Natural killer (NK) cells provide defense in the early stages of the innate immune response against viral infections by producing cytokines and causing cytotoxicity. The killer immunoglobulin-like receptors (KIRs) on NK cells regulate the inhibition and activation of NK-cell responses through rec...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acquired Immunodeficiency Syndrome
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes

Share to HLA-B Antigens

Share to Killer Cells, Natural

Share to Receptors, Immunologic

Share to Receptors, KIR

Share to Receptors, KIR3DS1

Source

Identifiers

PMID: 12134147
DOI: 10.1038/ng934

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12134147-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS.PMID 12134147Read ↗

Increased proportion of KIR3DS1 homozygotes in HIV-exposed uninfected individuals.Semantic proximity Read ↗

Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1.Semantic proximity Read ↗

KIR3DS1/L1 and HLA-Bw4-80I are associated with HIV disease progression among HIV typical progressors and long-term nonprogressors.Semantic proximity Read ↗

Under representation of the inhibitory KIR3DL1 molecule and the KIR3DL1+/BW4+ complex in HIV exposed seronegative individuals.Semantic proximity Read ↗

Detection of KIR3DS1 on the cell surface of peripheral blood NK cells facilitates identification of a novel null allele and assessment of KIR3DS1 expression during HIV-1 infection.Semantic proximity Read ↗

Conferral of enhanced natural killer cell function by KIR3DS1 in early human immunodeficiency virus type 1 infection.Semantic proximity Read ↗

A combined genotype of KIR3DL1 high expressing alleles and HLA-B*57 is associated with a reduced risk of HIV infection.Semantic proximity Read ↗

Impact of HLA Allele-KIR Pairs on HIV Clinical Outcome in South Africa.Semantic proximity Read ↗

Natural killer cell-mediated innate sieve effect on HIV-1: the impact of KIR/HLA polymorphism on HIV-1 subtype-specific acquisition in east Africa.Semantic proximity Read ↗

Time to seroconversion in HIV-exposed subjects carrying protective versus non protective KIR3DS1/L1 and HLA-B genotypes.Semantic proximity Read ↗

Protective genotypes in HIV infection reflect superior function of KIR3DS1+ over KIR3DL1+ CD8+ T cells.Semantic proximity Read ↗

Killer cell immunoglobulin-like receptor three domains long cytoplasmic tail 1 gene *007 may modulate disease progression of human immunodeficiency virus-1 infection in the Japanese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.