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Article

Dap160/intersectin binds and activates aPKC to regulate cell polarity and cell cycle progression.

Development (Cambridge, England) - 1 Aug 2008

Chabu Chiswili, Doe Chris Q

Abstract excerpt

The atypical protein kinase C (aPKC) is required for cell polarization of many cell types, and is upregulated in several human tumors. Despite its importance in cell polarity and growth control, relatively little is known about how aPKC activity is regulated. Here, we use a biochemical approach to identify Dynamin-associated protein 160 (Dap160; related to mammalian intersectin) as an aPKC-interacting protein in...

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Identifiers

PMID: 18614576
DOI: 10.1242/dev.024059
PMCID: PMC2683763

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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