Article
Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth.
Neuron - 22 Jul 2004
Marie Bruno, Sweeney Sean T, Poskanzer Kira E, Roos Jack, Kelly Regis B, Davis Graeme W
Abstract excerpt
Dap160/Intersectin is a multidomain adaptor protein that colocalizes with endocytic machinery in the periactive zone at the Drosophila NMJ. We have generated severe loss-of-function mutations that eliminate Dap160 protein from the NMJ. dap160 mutant synapses have decreased levels of essential end...
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