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Article

PDK1 Is a Regulator of Epidermal Differentiation that Activates and Organizes Asymmetric Cell Division.

Cell reports - 24 May 2016

Dainichi Teruki, Hayden Matthew S, Park Sung-Gyoo, Oh Hyunju, Seeley John J, Grinberg-Bleyer Yenkel, Beck Kristen M, Miyachi Yoshiki, Kabashima Kenji, Hashimoto Takashi, Ghosh Sankar

Abstract excerpt

Asymmetric cell division (ACD) in a perpendicular orientation promotes cell differentiation and organizes the stratified epithelium. However, the upstream cues regulating ACD have not been identified. Here, we report that phosphoinositide-dependent kinase 1 (PDK1) plays a critical role in establishing ACD in the epithelium. Production of phosphatidyl inositol triphosphate (PIP3) is localized to the apical side of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27184845
DOI: 10.1016/j.celrep.2016.04.051
PMCID: PMC4909264

Genes

PDK1
ACD
IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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