Article
Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function.
Molecular cell - 22 Apr 2011
Lee Tae Ho, Chen Chun-Hau, Suizu Futoshi, Huang Pengyu, Schiene-Fischer Cordelia, Daum Sebastian, Zhang Yan Jessie, Goate Alison, Chen Ruey-Hwa, Zhou Xiao Zhen, Lu Kun Ping
Abstract excerpt
Pin1 is a phospho-specific prolyl isomerase that regulates numerous key signaling molecules and whose deregulation contributes to disease notably cancer. However, since prolyl isomerases are often believed to be constitutively active, little is known whether and how Pin1 catalytic activity is regulated. Here, we identify death-associated protein kinase 1 (DAPK1), a known tumor suppressor, as a kinase responsible...
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