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Article

Drosophila aPKC is required for mitotic spindle orientation during symmetric division of epithelial cells.

Development (Cambridge, England) - 1 Feb 2012

Guilgur Leonardo G, Prudêncio Pedro, Ferreira Tânia, Pimenta-Marques Ana Rita, Martinho Rui Gonçalo

Abstract excerpt

Epithelial cells mostly orient the spindle along the plane of the epithelium (planar orientation) for mitosis to produce two identical daughter cells. The correct orientation of the spindle relies on the interaction between cortical polarity components and astral microtubules. Recent studies in mammalian tissue culture cells suggest that the apically localised atypical protein kinase C (aPKC) is important for the...

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PMID: 22223679
DOI: 10.1242/dev.071027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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