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Article

A mouse homologue of Drosophila pins can asymmetrically localize and substitute for pins function in Drosophila neuroblasts.

Journal of cell science - 1 Mar 2003

Yu Fengwei, Morin Xavier, Kaushik Rachna, Bahri Sami, Yang Xiaohang, Chia William

Abstract excerpt

Asymmetric cell division is a fundamental mechanism used to generate cellular diversity in invertebrates and vertebrates. In Drosophila, asymmetric division of neuroblasts is achieved by the asymmetric segregation of cell fate determinants Prospero and Numb into the basal daughter cell. Asymmetric segregation of cell fate determinants requires an apically localized protein complex that includes Inscuteable, Pins,...

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PMID: 12571286
DOI: 10.1242/jcs.00297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A mouse homologue of Drosophila pins can asymmetrically localize and substitute for pins function in Drosophila neuroblasts.PMID 12571286Read ↗

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Developmental stage-dependent transcriptional regulatory pathways control neuroblast lineage progression.Semantic proximity Read ↗

Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts.Semantic proximity Read ↗

cdc2 links the Drosophila cell cycle and asymmetric division machineries.Semantic proximity Read ↗

Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation.Semantic proximity Read ↗

Partner of Numb colocalizes with Numb during mitosis and directs Numb asymmetric localization in Drosophila neural and muscle progenitors.Semantic proximity Read ↗

Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions.Semantic proximity Read ↗

Cell Polarity Regulates Biased Myosin Activity and Dynamics during Asymmetric Cell Division via Drosophila Rho Kinase and Protein Kinase N.Semantic proximity Read ↗

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