Article
A general and accurate approach for computing the statistical power of the transmission disequilibrium test for complex disease genes.
Genetic epidemiology - 1 Jul 2001
Chen W M, Deng H W
Abstract excerpt
Transmission disequilibrium test (TDT) is a nuclear family-based analysis that can test linkage in the presence of association. It has gained extensive attention in theoretical investigation and in practical application; in both cases, the accuracy and generality of the power computation of the TDT are crucial. Despite extensive investigations, previous approaches for computing the statistical power of the TDT...
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