Detailed analysis of the relative power of direct and indirect association studies and the implications for their interpretation.

doi:10.1159/000101424

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Article

Detailed analysis of the relative power of direct and indirect association studies and the implications for their interpretation.

Human heredity - 1 Jan 2007

Moskvina V, O'Donovan M C

Abstract excerpt

OBJECTIVES: Genetic association studies are usually based upon restricted sets of 'tag' markers selected to represent the total sequence variation. Tag selection is often determined by some threshold for the r(2) coefficients of linkage disequilibrium (LD) between tag and untyped markers, it bein...

Topics

Gene Frequency
Genetic Markers
Genetic Predisposition to Disease
Genetic Techniques
Genetics, Medical
Haplotypes
Humans
Linkage Disequilibrium
Mathematics
Models, Statistical
Polymorphism, Single Nucleotide
Sample Size

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