Article
Detailed analysis of the relative power of direct and indirect association studies and the implications for their interpretation.
Human heredity - 1 Jan 2007
Moskvina V, O'Donovan M C
Abstract excerpt
OBJECTIVES: Genetic association studies are usually based upon restricted sets of 'tag' markers selected to represent the total sequence variation. Tag selection is often determined by some threshold for the r(2) coefficients of linkage disequilibrium (LD) between tag and untyped markers, it being widely assumed that power to detect an effect at the untyped sites is retained by typing the tag marker in a sample...
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