Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The impact of phenotypic and genetic heterogeneity on results of genome wide association studies of complex diseases.

PloS one - 1 Jan 2013

Manchia Mirko, Cullis Jeffrey, Turecki Gustavo, Rouleau Guy A, Uher Rudolf, Alda Martin

Abstract excerpt

Phenotypic misclassification (between cases) has been shown to reduce the power to detect association in genetic studies. However, it is conceivable that complex traits are heterogeneous with respect to individual genetic susceptibility and disease pathophysiology, and that the effect of heterogeneity has a larger magnitude than the effect of phenotyping errors. Although an intuitively clear concept, the effect...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

Share to Genetic Heterogeneity

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Phenotype

Share to Sample Size

Source

Open in PubMed Open full text

Identifiers

PMID: 24146854
DOI: 10.1371/journal.pone.0076295
PMCID: PMC3795757

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The impact of phenotypic and genetic heterogeneity on results of genome wide association studies of complex diseases.PMID 24146854Read ↗

Genetic heterogeneity: Challenges, impacts, and methods through an associative lens.Semantic proximity Read ↗

Incorporation of Heterogeneity in a Case-Control Study Through a Mixture ModelSemantic proximity Read ↗

The impact of population heterogeneity on risk estimation in genetic counseling.Semantic proximity Read ↗

Meta-analysis of genetic association studies under heterogeneity.Semantic proximity Read ↗

Identifying systematic heterogeneity patterns in genetic association meta-analysis studies.Semantic proximity Read ↗

Type 1 diabetes: heterogeneity in heritability.Semantic proximity Read ↗

Exploring the Major Sources and Extent of Heterogeneity in a Genome-Wide Association Meta-Analysis.Semantic proximity Read ↗

Heterogeneity: GAW Group 15.Semantic proximity Read ↗

A weighted U statistic for association analyses considering genetic heterogeneity.Semantic proximity Read ↗

A robust association test for detecting genetic variants with heterogeneous effects.Semantic proximity Read ↗

Detecting and Adjusting for Hidden Biases due to Phenotype Misclassification in Genome-Wide Association StudiesSemantic proximity Read ↗

On the contribution of genetic heterogeneity to complex traitsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.