Activation of c-K-ras is frequent in pancreatic carcinomas of Syrian hamsters, but is absent in pancreatic tumors of rats.

doi:10.1093/carcin/12.8.1477

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Article

Activation of c-K-ras is frequent in pancreatic carcinomas of Syrian hamsters, but is absent in pancreatic tumors of rats.

Carcinogenesis - 1 Aug 1991

van Kranen H J, Vermeulen E, Schoren L, Bax J, Woutersen R A, van Iersel P, van Kreijl C F, Scherer E

Abstract excerpt

We have investigated the presence of mutations in ras genes at codons 12, 13 and 61 in chemically induced pancreatic tumors of rats and Syrian hamsters. Mutations were detected by means of allele-specific oligonucleotide hybridization to ras sequences amplified in vitro by the polymerase chain re...

Topics

Adenocarcinoma
Amino Acid Sequence
Animals
Base Sequence
Codon
Cricetinae
Exons
Gene Expression Regulation, Neoplastic
Genes, ras
Introns
Male
Molecular Sequence Data
Mutation
Pancreatic Neoplasms
Polymerase Chain Reaction
Rats

Source

Open in PubMed

Identifiers

PMID: 1860169
DOI: 10.1093/carcin/12.8.1477

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1860169-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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