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Article

Mutational activation of the c-K-ras gene in human pancreatic carcinoma.

Bailliere's clinical gastroenterology - 1 Mar 1990

Shibata D, Capella G, Perucho M

Abstract excerpt

We have reported the presence of c-K-ras oncogenes activated by single point mutations at codon 12 in a vast majority of human pancreatic carcinomas. Formalin-fixed, paraffin-embedded specimens from surgical resections, autopsies and biopsies were used as well as snap frozen surgical specimens. The high oncogene incidence has been confirmed in other studies and indicate that somatic mutational activation of the...

Topics

Adenocarcinoma
Gene Expression Regulation, Neoplastic
Genes, ras
Humans
Mutation
Pancreatic Neoplasms
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1976394
DOI: 10.1016/0950-3528(90)90044-h

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1976394-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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